Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
SM	JLC	2.48e-03	1.43e-02	7.44e-05	5.84e-04
JLC	SM	4.63e-02	5.07e-04	1.58e-04	7.04e-28



Evaluating how well SM genes are linked to JLC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SM	JLC	0.84	3.77	3.17	1.61	3.93
JLC	SM	0.79	2.84	4.56	2.26	12.89

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SM	JLC	0.01	21.26	18.02	3.41	16.28
JLC	SM	0.02	4.52	7.02	4.28	15.96

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
SM	146	145	RNASE12
JLC	13	10	NEMO;TRIF;UNC93B