Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Control	JLC	2.11e-02	6.17e-03	2.31e-07	4.06e-05
JLC	Control	5.82e-04	1.40e-04	2.79e-05	4.15e-28



Evaluating how well Control genes are linked to JLC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Control	JLC	0.90	2.47	5.08	2.64	4.25
JLC	Control	0.78	1.97	4.71	2.10	10.90

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Control	JLC	0.01	4.63	13.75	7.62	3.75
JLC	Control	0.02	5.31	6.13	5.48	13.07

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Control	161	160	RNASE12
JLC	13	10	UNC93B;TRIF;NEMO