Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Controls Exclusive	ViralGS	2.79e-02	6.09e-04	1.04e-22	9.96e-15
ViralGS Exclusive	Controls	1.87e-06	3.60e-03	1.45e-09	6.68e-24
Controls Exclusive	ViralGS Exclusive	3.36e-02	2.36e-03	1.59e-21	2.47e-13
ViralGS Exclusive	Controls Exclusive	8.56e-07	8.01e-03	2.88e-08	1.10e-22
Controls Exclusive	Overlap	3.11e-01	1.14e-01	2.45e-04	1.05e-03
ViralGS Exclusive	Overlap	2.24e-04	1.69e-04	1.86e-04	3.37e-04
Overlap	Exclusives	5.33e-16	1.93e-10	5.65e-75	4.73e-49



Evaluating how well Controls genes are linked to ViralGS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Controls Exclusive	ViralGS	0.75	1.61	4.70	2.21	10.50
ViralGS Exclusive	Controls	0.76	-0.92	3.09	3.02	10.49
Controls Exclusive	ViralGS Exclusive	0.75	1.66	4.48	2.37	8.81
ViralGS Exclusive	Controls Exclusive	0.75	-1.26	2.99	2.96	10.15
Controls Exclusive	Overlap	0.93	1.26	2.63	1.85	3.20
ViralGS Exclusive	Overlap	0.98	2.50	4.83	2.78	3.67
Overlap	Exclusives	0.79	3.53	8.44	1.84	15.11

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Controls Exclusive	ViralGS	0.02	1.80	2.96	4.06	8.07
ViralGS Exclusive	Controls	0.02	-1.07	4.17	4.69	13.55
Controls Exclusive	ViralGS Exclusive	0.02	1.86	3.94	4.82	6.23
ViralGS Exclusive	Controls Exclusive	0.02	-1.38	3.27	4.15	15.81
Controls Exclusive	Overlap	0.00	-0.41	-0.94	1.51	-0.05
ViralGS Exclusive	Overlap	0.01	3.01	72.15	12.09	41.90
Overlap	Exclusives	0.05	8.58	18.57	3.97	38.84

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Controls Exclusive	157	156	RNASE12
ViralGS Exclusive	104	100	HLA-DRB4;SNORA31;MBL3P;ABO
Overlap	4	4