Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ReactMild	JLC	1.99e-07	9.93e-07	2.56e-08	8.30e-08
JLC	ReactMild	1.67e-01	6.93e-05	3.43e-05	3.66e-09



Evaluating how well ReactMild genes are linked to JLC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ReactMild	JLC	0.98	3.18	4.28	3.03	5.27
JLC	ReactMild	0.77	2.00	4.79	2.31	6.51

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ReactMild	JLC	0.02	13.27	8.22	19.18	10.91
JLC	ReactMild	0.01	5.89	11.27	8.54	3.30

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ReactMild	47	46	HYAL3
JLC	13	10	TRIF;UNC93B;NEMO