Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Severe Exclusive	CovidGS	3.26e-01	3.94e-05	4.11e-04	5.89e-14
CovidGS Exclusive	Severe	1.33e-01	2.42e-01	3.03e-04	3.02e-07
Severe Exclusive	CovidGS Exclusive	2.26e-01	2.22e-05	3.78e-03	4.25e-13
CovidGS Exclusive	Severe Exclusive	3.74e-01	2.66e-01	1.43e-03	4.49e-07
Severe Exclusive	Overlap	4.70e-02	7.76e-01	4.17e-02	9.64e-04
CovidGS Exclusive	Overlap	1.69e-04	1.69e-04	1.69e-04	2.45e-04
Overlap	Exclusives	2.71e-07	4.89e-02	7.15e-49	3.89e-12



Evaluating how well Severe genes are linked to CovidGS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Severe Exclusive	CovidGS	0.75	1.07	4.67	2.07	7.91
CovidGS Exclusive	Severe	0.64	2.20	2.52	1.62	6.10
Severe Exclusive	CovidGS Exclusive	0.74	1.39	4.59	1.77	7.43
CovidGS Exclusive	Severe Exclusive	0.64	2.03	2.28	1.19	6.79
Severe Exclusive	Overlap	0.91	-0.25	0.69	0.37	3.12
CovidGS Exclusive	Overlap	0.99	2.06	3.72	2.14	3.13
Overlap	Exclusives	0.65	1.83	2.02	0.21	6.42

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Severe Exclusive	CovidGS	0.01	-0.77	4.08	0.90	2.64
CovidGS Exclusive	Severe	0.01	1.60	2.75	2.02	4.74
Severe Exclusive	CovidGS Exclusive	0.01	-0.35	3.45	0.75	6.44
CovidGS Exclusive	Severe Exclusive	0.01	0.74	1.45	1.04	4.52
Severe Exclusive	Overlap	0.00	-1.11	0.30	-0.67	0.68
CovidGS Exclusive	Overlap	0.01	1.49	79.86	11.26	20.35
Overlap	Exclusives	0.03	13.63	17.37	3.42	22.21

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Severe Exclusive	147	144	HYAL3;NLRC3;SLC37A4
CovidGS Exclusive	74	71	ABO;MBL3P;HLA-DRB4
Overlap	4	4