Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Severe	JLC	1.62e-02	4.38e-03	1.37e-03	2.37e-03
JLC	Severe	2.14e-03	3.53e-01	6.05e-02	1.28e-04



Evaluating how well Severe genes are linked to JLC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Severe	JLC	0.83	1.24	3.76	1.44	3.58
JLC	Severe	0.62	0.42	0.78	0.07	4.64

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Severe	JLC	0.00	0.56	4.86	1.07	0.78
JLC	Severe	0.01	1.45	1.27	0.78	6.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Severe	151	148	HYAL3;SLC37A4;NLRC3
JLC	13	10	UNC93B;NEMO;TRIF