Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Mild Exclusive	CovidGS	3.00e-01	1.70e-02	7.45e-04	3.33e-09
CovidGS Exclusive	Mild	8.10e-02	1.47e-01	5.33e-05	4.72e-05
Mild Exclusive	CovidGS Exclusive	3.63e-01	3.52e-02	1.71e-03	7.67e-09
CovidGS Exclusive	Mild Exclusive	4.99e-02	1.40e-01	8.89e-05	1.06e-04
Mild Exclusive	Overlap	3.67e-01	4.91e-01	2.52e-01	1.95e-01
CovidGS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.05e-01
Overlap	Exclusives	4.67e-08	6.80e-09	7.51e-18	1.42e-15



Evaluating how well Mild genes are linked to CovidGS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Mild Exclusive	CovidGS	0.73	0.52	3.74	1.31	7.13
CovidGS Exclusive	Mild	0.61	2.00	1.64	1.02	4.49
Mild Exclusive	CovidGS Exclusive	0.72	0.38	3.61	1.34	7.26
CovidGS Exclusive	Mild Exclusive	0.61	1.39	1.97	1.09	4.22
Mild Exclusive	Overlap	0.85	0.67	0.73	0.80	1.33
CovidGS Exclusive	Overlap	1.00	2.02	1.77	2.03	1.69
Overlap	Exclusives	0.69	1.02	6.94	1.02	10.44

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Mild Exclusive	CovidGS	0.01	-0.36	3.09	0.43	3.72
CovidGS Exclusive	Mild	0.01	1.53	1.40	0.98	2.82
Mild Exclusive	CovidGS Exclusive	0.01	-0.62	2.74	0.51	8.69
CovidGS Exclusive	Mild Exclusive	0.01	0.74	0.91	0.72	3.24
Mild Exclusive	Overlap	0.00	-0.16	-0.12	-0.04	0.81
CovidGS Exclusive	Overlap	0.01	100.51	108.45	40.97	5.33
Overlap	Exclusives	0.03	4.11	21.05	2.81	19.65

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Mild Exclusive	134	130	HYAL3;PLPPR4;PLPPR2;ADH1C
CovidGS Exclusive	77	74	ABO;HLA-DRB4;MBL3P
Overlap	1	1