Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
SM_35 Exclusive	JLC	6.81e-10	2.10e-08	6.81e-10	2.27e-09
JLC Exclusive	SM_35	5.32e-12	2.69e-18	3.77e-16	1.54e-30
SM_35 Exclusive	JLC Exclusive	2.10e-05	3.95e-05	2.19e-05	4.13e-05
JLC Exclusive	SM_35 Exclusive	7.30e-10	3.22e-16	1.17e-12	1.57e-27
SM_35 Exclusive	Overlap	2.10e-05	2.10e-05	2.10e-05	2.19e-05
JLC Exclusive	Overlap	2.10e-05	2.10e-05	2.10e-05	2.19e-05
Overlap	Exclusives	4.88e-16	1.41e-19	4.48e-28	3.36e-31



Evaluating how well SM_35 genes are linked to JLC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SM_35 Exclusive	JLC	0.99	3.98	5.62	3.08	5.46
JLC Exclusive	SM_35	0.89	2.46	10.36	2.86	12.36
SM_35 Exclusive	JLC Exclusive	0.99	4.35	4.73	2.67	3.78
JLC Exclusive	SM_35 Exclusive	0.89	2.42	9.59	2.71	10.91
SM_35 Exclusive	Overlap	1.00	2.76	3.66	2.57	4.60
JLC Exclusive	Overlap	1.00	1.96	3.38	2.08	4.00
Overlap	Exclusives	0.89	2.71	10.26	2.78	10.74

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SM_35 Exclusive	JLC	0.08	111.61	187.37	125.19	172.34
JLC Exclusive	SM_35	0.05	10.38	55.87	11.77	88.63
SM_35 Exclusive	JLC Exclusive	0.01	44.50	14.81	18.38	16.08
JLC Exclusive	SM_35 Exclusive	0.03	9.08	38.19	9.42	39.84
SM_35 Exclusive	Overlap	0.10	20.49	179.69	195.36	347.06
JLC Exclusive	Overlap	0.05	48.06	157.56	43.90	62.07
Overlap	Exclusives	0.08	27.52	98.53	30.49	121.38

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
SM_35 Exclusive	73	70	HLA-DRB4;MBL3P;ABO
JLC Exclusive	8	5	UNC93B;TRIF;NEMO
Overlap	5	5