Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
19Controls	ViralGS	6.93e-03	1.47e-02	6.14e-01	1.98e-03
ViralGS	19Controls	1.78e-01	8.49e-01	8.10e-01	6.81e-01



Evaluating how well 19Controls genes are linked to ViralGS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
19Controls	ViralGS	0.57	-1.40	-5.40	-1.40	3.18
ViralGS	19Controls	0.53	-0.89	-0.43	-0.35	0.39

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
19Controls	ViralGS	0.01	-0.85	-2.79	-0.94	1.26
ViralGS	19Controls	0.00	-0.72	-0.40	-0.54	-0.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
19Controls	19	18	CSNK2A3
ViralGS	108	104	MBL3P;HLA-DRB4;ABO;SNORA31