Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Overlapping_method_genes Exclusive	GS	1.83e-01	1.88e-01	1.18e-03	5.57e-08
GS Exclusive	Overlapping_method_genes	6.35e-02	1.34e-01	2.25e-07	1.88e-05
Overlapping_method_genes Exclusive	GS Exclusive	1.60e-01	1.69e-01	2.93e-03	1.29e-08
GS Exclusive	Overlapping_method_genes Exclusive	1.86e-01	1.82e-01	3.74e-07	3.23e-05
Overlapping_method_genes Exclusive	Overlap	5.40e-01	5.93e-01	5.40e-01	6.74e-01
GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	9.97e-23	1.24e-19	5.51e-40	7.73e-42



Evaluating how well Overlapping_method_genes genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Overlapping_method_genes Exclusive	GS	0.70	0.30	1.20	0.86	6.75
GS Exclusive	Overlapping_method_genes	0.65	2.37	1.92	1.63	5.35
Overlapping_method_genes Exclusive	GS Exclusive	0.70	0.23	1.27	0.85	5.75
GS Exclusive	Overlapping_method_genes Exclusive	0.64	1.68	1.76	1.93	5.39
Overlapping_method_genes Exclusive	Overlap	0.65	-0.03	0.55	0.11	0.73
GS Exclusive	Overlap	1.00	3.13	2.54	2.50	2.23
Overlap	Exclusives	0.80	3.88	10.05	3.26	15.03

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Overlapping_method_genes Exclusive	GS	0.01	-0.34	1.95	1.32	6.85
GS Exclusive	Overlapping_method_genes	0.01	5.28	2.90	3.46	3.65
Overlapping_method_genes Exclusive	GS Exclusive	0.01	-0.50	2.16	1.05	5.99
GS Exclusive	Overlapping_method_genes Exclusive	0.01	1.81	0.71	2.18	1.98
Overlapping_method_genes Exclusive	Overlap	0.00	1.99	-0.18	1.07	0.43
GS Exclusive	Overlap	0.07	824.54	224.95	245.23	71.04
Overlap	Exclusives	0.06	13.24	45.61	11.99	60.98

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Overlapping_method_genes Exclusive	110	107	NT5C3A;NT5C3B;DNPH1
GS Exclusive	86	84	CENTD2;TMEM195
Overlap	2	2