Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
35	Casa	9.16e-05	1.03e-04	1.49e-05	2.98e-05
Casa	35	6.33e-02	6.50e-02	2.95e-02	4.35e-03



Evaluating how well 35 genes are linked to Casa genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
35	Casa	0.91	2.99	4.46	2.50	4.08
Casa	35	0.69	1.90	1.72	1.67	3.63

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
35	Casa	0.00	2.83	3.83	4.83	7.04
Casa	35	0.01	5.51	4.79	2.25	5.75

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
35	35	34	GIMD1
Casa	13	10	TRIF;NEMO;UNC93B