Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADfemale Exclusive	MIglobal	4.68e-03	5.43e-06	1.75e-04	1.58e-08
MIglobal Exclusive	ADfemale	5.83e-02	4.92e-04	1.27e-02	2.03e-03
ADfemale Exclusive	MIglobal Exclusive	6.54e-03	7.88e-06	1.74e-04	4.07e-09
MIglobal Exclusive	ADfemale Exclusive	6.89e-02	1.17e-03	2.31e-02	4.67e-03
ADfemale Exclusive	Overlap	2.28e-01	2.65e-01	1.49e-01	2.52e-01
MIglobal Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.05e-01
Overlap	Exclusives	1.46e-20	1.29e-19	1.35e-12	6.74e-23



Evaluating how well ADfemale genes are linked to MIglobal genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADfemale Exclusive	MIglobal	0.67	1.70	5.55	2.39	7.02
MIglobal Exclusive	ADfemale	0.61	3.65	2.90	3.72	2.62
ADfemale Exclusive	MIglobal Exclusive	0.67	1.54	5.42	2.20	7.13
MIglobal Exclusive	ADfemale Exclusive	0.61	3.53	2.90	3.06	2.45
ADfemale Exclusive	Overlap	0.86	1.23	1.31	1.71	1.01
MIglobal Exclusive	Overlap	0.99	2.18	1.78	2.00	1.56
Overlap	Exclusives	0.70	2.23	9.39	2.17	10.66

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADfemale Exclusive	MIglobal	0.01	1.00	5.10	2.22	5.59
MIglobal Exclusive	ADfemale	0.00	2.90	1.35	2.73	1.34
ADfemale Exclusive	MIglobal Exclusive	0.01	1.09	4.74	2.08	4.02
MIglobal Exclusive	ADfemale Exclusive	0.00	3.22	0.86	3.12	1.58
ADfemale Exclusive	Overlap	0.00	-0.08	-0.15	0.50	0.09
MIglobal Exclusive	Overlap	0.00	1.21	4.89	2.15	0.26
Overlap	Exclusives	0.04	7.10	33.85	3.13	24.52

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADfemale Exclusive	47	46	C20orf111
MIglobal Exclusive	138	137	UGT2A1
Overlap	1	1