Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
cont16	CovidGS	6.23e-01	6.27e-01	2.22e-03	2.93e-05
CovidGS	cont16	3.99e-01	9.18e-01	6.89e-02	5.54e-02



Evaluating how well cont16 genes are linked to CovidGS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cont16	CovidGS	0.66	-0.66	-1.21	-0.57	4.83
CovidGS	cont16	0.67	-0.55	-0.00	0.45	2.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cont16	CovidGS	0.01	-0.67	-1.26	-0.62	2.97
CovidGS	cont16	0.00	-0.54	-0.46	0.16	-0.06

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
cont16	16	16	
CovidGS	78	75	MBL3P;HLA-DRB4;ABO