Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Cont16	Casanova	1.52e-01	2.52e-02	6.28e-01	5.40e-01
Casanova	Cont16	3.17e-02	8.89e-01	1.67e-01	1.80e-02



Evaluating how well Cont16 genes are linked to Casanova genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cont16	Casanova	0.55	-1.36	-3.07	-1.01	0.39
Casanova	Cont16	0.68	-0.81	-0.29	0.05	2.61

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cont16	Casanova	0.00	-0.43	-1.48	-0.45	-0.28
Casanova	Cont16	0.00	-0.67	-0.70	-0.41	0.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Cont16	16	16	
Casanova	13	10	NEMO;TRIF;UNC93B