Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EastAsian_EA-ML_genes Exclusive	GS_genes	2.34e-01	2.52e-02	9.06e-02	2.92e-05
GS_genes Exclusive	EastAsian_EA-ML_genes	2.04e-06	2.31e-02	1.15e-01	2.04e-01
EastAsian_EA-ML_genes Exclusive	GS_genes Exclusive	8.04e-02	1.73e-02	5.26e-02	3.15e-05
GS_genes Exclusive	EastAsian_EA-ML_genes Exclusive	1.66e-06	1.78e-02	1.59e-01	1.24e-01
EastAsian_EA-ML_genes Exclusive	Overlap	1.54e-01	2.99e-02	2.27e-01	7.39e-02
GS_genes Exclusive	Overlap	1.38e-03	1.38e-03	1.38e-03	1.38e-03
Overlap	Exclusives	1.14e-08	6.00e-08	1.85e-19	1.07e-12



Evaluating how well EastAsian_EA-ML_genes genes are linked to GS_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EastAsian_EA-ML_genes Exclusive	GS_genes	0.63	-0.60	-2.21	-1.10	4.22
GS_genes Exclusive	EastAsian_EA-ML_genes	0.48	-2.94	-2.37	-1.65	-0.81
EastAsian_EA-ML_genes Exclusive	GS_genes Exclusive	0.63	-0.95	-2.40	-1.23	4.14
GS_genes Exclusive	EastAsian_EA-ML_genes Exclusive	0.47	-3.22	-2.53	-1.94	-1.37
EastAsian_EA-ML_genes Exclusive	Overlap	0.76	1.63	1.96	1.26	1.70
GS_genes Exclusive	Overlap	1.00	3.94	3.31	3.08	3.02
Overlap	Exclusives	0.64	3.00	4.09	2.54	7.01

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EastAsian_EA-ML_genes Exclusive	GS_genes	0.01	-1.18	-2.66	-1.39	2.28
GS_genes Exclusive	EastAsian_EA-ML_genes	0.01	3.65	1.94	2.05	1.87
EastAsian_EA-ML_genes Exclusive	GS_genes Exclusive	0.01	-1.46	-2.50	-1.39	2.65
GS_genes Exclusive	EastAsian_EA-ML_genes Exclusive	0.01	-1.57	-1.26	-1.08	-0.87
EastAsian_EA-ML_genes Exclusive	Overlap	0.00	1.27	1.06	0.45	-0.12
GS_genes Exclusive	Overlap	0.09	818.48	411.50	250.11	186.30
Overlap	Exclusives	0.06	29.48	42.66	18.42	42.24

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EastAsian_EA-ML_genes Exclusive	172	164	FAM227B;DNPH1;WDR93;NLRP2;C11orf42;C17orf66;MAP3K7CL;FAM105A
GS_genes Exclusive	85	83	CENTD2;TMEM195
Overlap	3	3