Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EastAsian_genes Exclusive	GS_genes	3.13e-02	6.48e-01	2.58e-16	2.48e-11
GS_genes Exclusive	EastAsian_genes	4.26e-05	2.55e-03	3.54e-17	1.07e-21
EastAsian_genes Exclusive	GS_genes Exclusive	1.38e-01	9.29e-01	2.95e-15	8.19e-11
GS_genes Exclusive	EastAsian_genes Exclusive	9.35e-06	1.03e-02	2.47e-15	1.06e-20
EastAsian_genes Exclusive	Overlap	4.56e-02	4.39e-01	4.86e-03	1.33e-02
GS_genes Exclusive	Overlap	1.32e-05	6.37e-06	2.74e-06	6.65e-06
Overlap	Exclusives	9.86e-18	7.89e-20	6.28e-55	7.24e-54



Evaluating how well EastAsian_genes genes are linked to GS_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EastAsian_genes Exclusive	GS_genes	0.76	1.88	0.12	2.58	7.96
GS_genes Exclusive	EastAsian_genes	0.75	-2.71	3.36	2.74	10.20
EastAsian_genes Exclusive	GS_genes Exclusive	0.75	1.62	0.20	2.22	8.21
GS_genes Exclusive	EastAsian_genes Exclusive	0.75	-3.52	2.49	2.53	10.60
EastAsian_genes Exclusive	Overlap	0.82	-0.02	-0.53	1.30	2.93
GS_genes Exclusive	Overlap	0.99	3.47	3.40	4.14	4.05
Overlap	Exclusives	0.83	5.59	10.65	2.97	21.36

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EastAsian_genes Exclusive	GS_genes	0.02	3.85	1.69	8.39	12.16
GS_genes Exclusive	EastAsian_genes	0.03	-0.66	9.27	8.98	22.38
EastAsian_genes Exclusive	GS_genes Exclusive	0.02	2.85	1.20	7.77	24.60
GS_genes Exclusive	EastAsian_genes Exclusive	0.02	-2.23	3.79	4.93	17.53
EastAsian_genes Exclusive	Overlap	0.00	4.82	2.83	7.67	2.96
GS_genes Exclusive	Overlap	0.08	98.09	246.12	260.82	389.08
Overlap	Exclusives	0.09	29.36	56.22	19.82	103.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EastAsian_genes Exclusive	166	165	RNASE12
GS_genes Exclusive	82	80	CENTD2;TMEM195
Overlap	6	6