Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EastAsian_genes Exclusive	GS_genes	4.90e-03	1.79e-03	2.39e-07	3.36e-12
GS_genes Exclusive	EastAsian_genes	2.38e-03	1.73e-05	1.65e-19	6.73e-15
EastAsian_genes Exclusive	GS_genes Exclusive	1.21e-02	4.37e-03	1.07e-06	5.19e-12
GS_genes Exclusive	EastAsian_genes Exclusive	1.07e-03	4.97e-05	2.02e-18	8.14e-15
EastAsian_genes Exclusive	Overlap	1.15e-02	2.80e-02	1.15e-02	1.42e-02
GS_genes Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.22e-02
Overlap	Exclusives	2.38e-71	1.65e-49	4.05e-138	2.11e-88



Evaluating how well EastAsian_genes genes are linked to GS_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EastAsian_genes Exclusive	GS_genes	0.75	1.02	4.12	2.41	7.01
GS_genes Exclusive	EastAsian_genes	0.66	2.86	5.76	2.19	10.01
EastAsian_genes Exclusive	GS_genes Exclusive	0.74	1.07	3.43	2.46	8.67
GS_genes Exclusive	EastAsian_genes Exclusive	0.66	3.95	5.48	2.39	9.63
EastAsian_genes Exclusive	Overlap	0.98	1.90	2.19	2.61	2.41
GS_genes Exclusive	Overlap	0.99	2.47	3.47	2.82	2.68
Overlap	Exclusives	0.83	3.77	18.83	3.41	22.54

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EastAsian_genes Exclusive	GS_genes	0.01	-1.11	5.24	2.14	9.87
GS_genes Exclusive	EastAsian_genes	0.02	4.23	5.60	3.47	9.43
EastAsian_genes Exclusive	GS_genes Exclusive	0.01	-1.34	4.95	1.69	11.85
GS_genes Exclusive	EastAsian_genes Exclusive	0.02	4.77	4.41	3.45	9.36
EastAsian_genes Exclusive	Overlap	0.00	4.45	4.53	14.14	2.24
GS_genes Exclusive	Overlap	0.05	205.70	273.97	184.15	281.33
Overlap	Exclusives	0.08	9.59	46.51	6.72	71.23

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EastAsian_genes Exclusive	272	268	DNPH1;NT5C3B;NT5C3A;DCP1A
GS_genes Exclusive	86	84	CENTD2;TMEM195
Overlap	2	2