Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EastAsian_genes	GS_genes	3.49e-01	3.09e-01	5.09e-01	3.29e-06
GS_genes	EastAsian_genes	3.87e-01	3.73e-01	1.27e-07	1.03e-02



Evaluating how well EastAsian_genes genes are linked to GS_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EastAsian_genes	GS_genes	0.67	-0.52	0.91	-0.32	6.05
GS_genes	EastAsian_genes	0.54	3.03	1.17	1.24	2.72

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EastAsian_genes	GS_genes	0.01	-1.18	2.91	-0.90	9.73
GS_genes	EastAsian_genes	0.02	2.94	0.40	0.53	0.69

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EastAsian_genes	416	410	NT5C3A;ZFP69B;CCDC180;NT5C3B;STPG2;ZFP69
GS_genes	88	86	TMEM195;CENTD2