Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
uk_genes	GS_genes	7.89e-05	2.80e-05	5.09e-11	1.56e-14
GS_genes	uk_genes	1.44e-04	1.03e-07	5.26e-19	1.63e-14



Evaluating how well uk_genes genes are linked to GS_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
uk_genes	GS_genes	0.76	2.00	4.30	2.99	8.48
GS_genes	uk_genes	0.69	5.22	6.25	3.45	9.38

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
uk_genes	GS_genes	0.01	0.89	10.20	4.55	13.98
GS_genes	uk_genes	0.02	5.67	7.55	5.07	10.81

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
uk_genes	208	202	OPLAH;TKFC;ETNPPL;SLC8B1;HYAL3;MRE11
GS_genes	88	86	TMEM195;CENTD2