Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
uk_genes Exclusive	GS_genes	8.45e-04	1.39e-03	1.40e-02	3.81e-06
GS_genes Exclusive	uk_genes	8.84e-02	5.19e-01	6.78e-03	1.28e-01
uk_genes Exclusive	GS_genes Exclusive	3.25e-03	1.36e-03	1.58e-02	5.70e-06
GS_genes Exclusive	uk_genes Exclusive	2.19e-02	6.35e-01	4.13e-02	2.69e-01
uk_genes Exclusive	Overlap	8.51e-01	6.33e-01	8.82e-01	5.27e-01
GS_genes Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	2.21e-22	6.88e-26	1.62e-21	3.74e-30



Evaluating how well uk_genes genes are linked to GS_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
uk_genes Exclusive	GS_genes	0.62	-1.40	-4.14	-1.37	3.81
GS_genes Exclusive	uk_genes	0.52	-0.72	0.06	0.10	0.72
uk_genes Exclusive	GS_genes Exclusive	0.62	-1.13	-4.47	-1.40	4.16
GS_genes Exclusive	uk_genes Exclusive	0.50	-1.80	-0.53	-0.62	0.21
uk_genes Exclusive	Overlap	0.56	-0.46	-0.84	-0.35	0.53
GS_genes Exclusive	Overlap	1.00	3.56	2.01	2.56	2.38
Overlap	Exclusives	0.79	2.77	10.62	2.87	10.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
uk_genes Exclusive	GS_genes	0.01	-0.92	-3.03	-0.94	0.74
GS_genes Exclusive	uk_genes	0.02	61.64	35.51	49.83	43.10
uk_genes Exclusive	GS_genes Exclusive	0.01	-0.84	-3.27	-1.02	0.57
GS_genes Exclusive	uk_genes Exclusive	0.00	-2.00	-0.81	-0.68	-0.21
uk_genes Exclusive	Overlap	0.00	-0.36	-0.88	-0.44	-0.20
GS_genes Exclusive	Overlap	0.42	6132.96	2584.69	1212.81	1323.37
Overlap	Exclusives	0.15	51.78	226.42	34.32	132.95

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
uk_genes Exclusive	45	43	C10orf71;LOH12CR1
GS_genes Exclusive	86	84	TMEM195;CENTD2
Overlap	2	2