Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
uk_genes Exclusive	GS_genes	4.46e-01	1.76e-01	3.48e-01	9.55e-10
GS_genes Exclusive	uk_genes	1.79e-01	1.72e-01	6.18e-05	8.08e-02
uk_genes Exclusive	GS_genes Exclusive	3.10e-01	8.98e-02	1.32e-01	5.69e-10
GS_genes Exclusive	uk_genes Exclusive	3.55e-01	2.82e-01	8.64e-05	1.17e-01
uk_genes Exclusive	Overlap	5.53e-01	1.84e-01	7.01e-01	5.93e-01
GS_genes Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	1.36e-20	7.23e-14	2.14e-17	1.23e-21



Evaluating how well uk_genes genes are linked to GS_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
uk_genes Exclusive	GS_genes	0.70	0.77	2.42	0.93	6.83
GS_genes Exclusive	uk_genes	0.53	2.95	1.14	1.50	1.42
uk_genes Exclusive	GS_genes Exclusive	0.71	0.72	2.69	1.13	7.61
GS_genes Exclusive	uk_genes Exclusive	0.53	2.70	0.54	1.24	1.15
uk_genes Exclusive	Overlap	0.55	-0.02	-0.77	-0.03	0.17
GS_genes Exclusive	Overlap	1.00	3.91	2.40	2.42	2.37
Overlap	Exclusives	0.71	3.03	8.58	3.60	10.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
uk_genes Exclusive	GS_genes	0.01	0.92	4.04	0.92	2.40
GS_genes Exclusive	uk_genes	0.01	2.87	7.18	3.29	3.44
uk_genes Exclusive	GS_genes Exclusive	0.01	0.80	3.90	1.13	8.85
GS_genes Exclusive	uk_genes Exclusive	0.01	0.51	0.72	1.04	0.06
uk_genes Exclusive	Overlap	0.00	-0.41	-0.60	-0.34	-0.24
GS_genes Exclusive	Overlap	0.16	321.66	685.78	165.27	171.05
Overlap	Exclusives	0.08	24.71	78.05	27.17	92.58

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
uk_genes Exclusive	123	118	C10orf71;LOC100507003;LOC100996648;IQCF6;ZSCAN31
GS_genes Exclusive	86	84	TMEM195;CENTD2
Overlap	2	2