Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EastAsian_genes Exclusive	GS_genes	1.46e-01	1.32e-01	1.22e-03	9.75e-08
GS_genes Exclusive	EastAsian_genes	9.59e-02	1.07e-01	1.38e-07	1.14e-05
EastAsian_genes Exclusive	GS_genes Exclusive	1.33e-01	1.77e-01	1.93e-03	2.43e-08
GS_genes Exclusive	EastAsian_genes Exclusive	1.94e-01	2.31e-01	5.40e-07	2.84e-05
EastAsian_genes Exclusive	Overlap	5.40e-01	6.47e-01	5.40e-01	6.20e-01
GS_genes Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	1.19e-23	6.35e-20	4.93e-38	7.89e-43



Evaluating how well EastAsian_genes genes are linked to GS_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EastAsian_genes Exclusive	GS_genes	0.70	0.15	1.43	0.82	5.79
GS_genes Exclusive	EastAsian_genes	0.65	1.69	2.17	1.73	4.90
EastAsian_genes Exclusive	GS_genes Exclusive	0.70	0.19	1.50	1.16	7.30
GS_genes Exclusive	EastAsian_genes Exclusive	0.64	2.03	2.10	1.58	5.15
EastAsian_genes Exclusive	Overlap	0.65	-0.12	0.79	0.23	0.63
GS_genes Exclusive	Overlap	1.00	2.75	2.49	2.66	2.15
Overlap	Exclusives	0.80	4.35	11.34	3.01	14.68

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EastAsian_genes Exclusive	GS_genes	0.01	-0.43	2.55	1.37	5.20
GS_genes Exclusive	EastAsian_genes	0.01	3.64	3.13	3.68	3.81
EastAsian_genes Exclusive	GS_genes Exclusive	0.01	-0.48	2.23	1.32	6.14
GS_genes Exclusive	EastAsian_genes Exclusive	0.01	2.12	0.85	1.28	3.51
EastAsian_genes Exclusive	Overlap	0.00	1.50	-0.15	3.08	0.87
GS_genes Exclusive	Overlap	0.07	407.06	245.73	368.78	177.30
Overlap	Exclusives	0.06	15.10	48.01	10.71	69.64

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EastAsian_genes Exclusive	110	107	DNPH1;NT5C3A;NT5C3B
GS_genes Exclusive	86	84	TMEM195;CENTD2
Overlap	2	2