Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EastAsian_genes Exclusive	GS_genes	6.23e-02	1.57e-01	1.98e-03	8.92e-08
GS_genes Exclusive	EastAsian_genes	9.10e-02	1.07e-01	1.45e-07	2.00e-05
EastAsian_genes Exclusive	GS_genes Exclusive	1.02e-01	2.26e-01	3.12e-03	1.48e-08
GS_genes Exclusive	EastAsian_genes Exclusive	1.46e-01	1.76e-01	4.12e-07	1.13e-05
EastAsian_genes Exclusive	Overlap	5.40e-01	6.06e-01	5.53e-01	6.47e-01
GS_genes Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	2.54e-24	8.24e-20	2.25e-38	1.13e-41



Evaluating how well EastAsian_genes genes are linked to GS_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EastAsian_genes Exclusive	GS_genes	0.70	-0.12	1.55	0.84	6.07
GS_genes Exclusive	EastAsian_genes	0.65	1.76	2.37	1.88	5.95
EastAsian_genes Exclusive	GS_genes Exclusive	0.70	0.17	1.42	0.91	6.45
GS_genes Exclusive	EastAsian_genes Exclusive	0.64	2.27	2.10	1.54	5.36
EastAsian_genes Exclusive	Overlap	0.65	0.15	0.63	0.11	0.58
GS_genes Exclusive	Overlap	1.00	3.33	2.74	2.96	2.43
Overlap	Exclusives	0.80	4.34	10.78	3.19	14.72

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EastAsian_genes Exclusive	GS_genes	0.01	-0.57	2.31	1.28	2.30
GS_genes Exclusive	EastAsian_genes	0.01	3.84	3.47	4.22	3.65
EastAsian_genes Exclusive	GS_genes Exclusive	0.01	-0.56	2.19	0.97	3.09
GS_genes Exclusive	EastAsian_genes Exclusive	0.01	1.93	0.62	1.60	1.56
EastAsian_genes Exclusive	Overlap	0.00	2.64	-0.09	1.06	0.04
GS_genes Exclusive	Overlap	0.07	637.76	269.71	454.57	239.98
Overlap	Exclusives	0.06	15.93	50.58	10.27	55.66

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EastAsian_genes Exclusive	110	107	NT5C3A;NT5C3B;DNPH1
GS_genes Exclusive	86	84	CENTD2;TMEM195
Overlap	2	2