Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
hg38_top72_genes Exclusive	BRCAgwas_GS	6.44e-01	1.89e-01	5.16e-03	1.56e-05
BRCAgwas_GS Exclusive	hg38_top72_genes	4.79e-01	4.30e-01	3.54e-02	2.53e-02
hg38_top72_genes Exclusive	BRCAgwas_GS Exclusive	6.40e-01	2.01e-01	3.83e-03	2.30e-05
BRCAgwas_GS Exclusive	hg38_top72_genes Exclusive	8.31e-01	8.10e-01	6.31e-02	9.61e-02
hg38_top72_genes Exclusive	Overlap	1.92e-01	1.92e-01	1.92e-01	1.79e-01
BRCAgwas_GS Exclusive	Overlap	7.03e-02	5.60e-02	1.31e-02	1.77e-02
Overlap	Exclusives	3.82e-03	7.02e-04	7.54e-24	4.00e-12



Evaluating how well hg38_top72_genes genes are linked to BRCAgwas_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_top72_genes Exclusive	BRCAgwas_GS	0.62	1.99	1.97	1.82	5.75
BRCAgwas_GS Exclusive	hg38_top72_genes	0.60	0.29	0.20	0.68	3.13
hg38_top72_genes Exclusive	BRCAgwas_GS Exclusive	0.61	1.64	1.90	1.92	4.35
BRCAgwas_GS Exclusive	hg38_top72_genes Exclusive	0.58	-0.05	-0.28	0.71	2.27
hg38_top72_genes Exclusive	Overlap	0.80	1.19	0.68	1.09	2.00
BRCAgwas_GS Exclusive	Overlap	0.89	1.48	1.72	1.91	2.90
Overlap	Exclusives	0.65	2.73	4.62	2.41	7.90

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_top72_genes Exclusive	BRCAgwas_GS	0.01	1.57	1.88	2.21	4.36
BRCAgwas_GS Exclusive	hg38_top72_genes	0.01	2.52	5.11	3.62	4.08
hg38_top72_genes Exclusive	BRCAgwas_GS Exclusive	0.01	1.02	1.04	1.48	4.07
BRCAgwas_GS Exclusive	hg38_top72_genes Exclusive	0.01	1.39	1.84	3.63	3.86
hg38_top72_genes Exclusive	Overlap	0.01	49.47	30.67	43.18	2.69
BRCAgwas_GS Exclusive	Overlap	0.00	4.01	14.23	9.11	0.05
Overlap	Exclusives	0.03	7.72	10.42	5.89	12.06

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
hg38_top72_genes Exclusive	68	67	MRM2
BRCAgwas_GS Exclusive	169	165	BORCS8;GATD1;MRTFA;PIDD1
Overlap	4	4