Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UKB_BRCA_STIRNGGenes Exclusive	BRCAgwas_GS	8.57e-05	1.17e-01	2.54e-03	9.49e-02
BRCAgwas_GS Exclusive	UKB_BRCA_STIRNGGenes	1.72e-03	1.66e-02	9.66e-02	4.07e-01
UKB_BRCA_STIRNGGenes Exclusive	BRCAgwas_GS Exclusive	2.82e-04	1.02e-01	7.98e-03	1.76e-01
BRCAgwas_GS Exclusive	UKB_BRCA_STIRNGGenes Exclusive	1.09e-03	1.24e-02	7.53e-02	2.39e-01
UKB_BRCA_STIRNGGenes Exclusive	Overlap	1.92e-01	1.92e-01	1.92e-01	2.05e-01
BRCAgwas_GS Exclusive	Overlap	5.13e-02	6.28e-02	1.26e-02	2.70e-02
Overlap	Exclusives	2.50e-02	2.00e-01	1.41e-33	3.36e-06



Evaluating how well UKB_BRCA_STIRNGGenes genes are linked to BRCAgwas_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB_BRCA_STIRNGGenes Exclusive	BRCAgwas_GS	0.54	-3.45	-2.35	-2.12	1.78
BRCAgwas_GS Exclusive	UKB_BRCA_STIRNGGenes	0.50	-1.95	-3.36	-1.58	-0.02
UKB_BRCA_STIRNGGenes Exclusive	BRCAgwas_GS Exclusive	0.54	-3.15	-2.74	-1.77	1.47
BRCAgwas_GS Exclusive	UKB_BRCA_STIRNGGenes Exclusive	0.49	-2.00	-3.52	-1.26	-0.35
UKB_BRCA_STIRNGGenes Exclusive	Overlap	0.64	-1.06	-0.40	-0.71	1.04
BRCAgwas_GS Exclusive	Overlap	0.89	1.54	2.07	1.99	2.81
Overlap	Exclusives	0.59	1.48	1.93	1.47	6.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB_BRCA_STIRNGGenes Exclusive	BRCAgwas_GS	0.01	-1.82	-0.97	-1.21	1.58
BRCAgwas_GS Exclusive	UKB_BRCA_STIRNGGenes	0.01	-1.38	-2.16	-1.21	-0.73
UKB_BRCA_STIRNGGenes Exclusive	BRCAgwas_GS Exclusive	0.01	-2.10	-1.99	-1.24	0.75
BRCAgwas_GS Exclusive	UKB_BRCA_STIRNGGenes Exclusive	0.01	-1.70	-3.00	-1.23	-1.07
UKB_BRCA_STIRNGGenes Exclusive	Overlap	0.01	16.27	19.33	17.14	6.52
BRCAgwas_GS Exclusive	Overlap	0.00	5.51	13.42	13.07	0.48
Overlap	Exclusives	0.03	5.03	5.74	3.73	8.69

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UKB_BRCA_STIRNGGenes Exclusive	207	197	KRBOX4;STPG2;MFSD13A;VPS11;MALRD1;PADI6;WHRN;CFAP45;MRM2;ETFBKMT
BRCAgwas_GS Exclusive	169	165	MRTFA;GATD1;BORCS8;PIDD1
Overlap	4	4