Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
hg38_Reactome_genes Exclusive	BRCAgwas_GS	5.37e-02	1.93e-01	3.67e-04	3.54e-05
BRCAgwas_GS Exclusive	hg38_Reactome_genes	1.43e-01	1.63e-01	1.18e-06	2.39e-09
hg38_Reactome_genes Exclusive	BRCAgwas_GS Exclusive	5.23e-02	1.85e-01	1.50e-03	1.58e-04
BRCAgwas_GS Exclusive	hg38_Reactome_genes Exclusive	1.20e-01	2.43e-01	3.10e-06	1.36e-08
hg38_Reactome_genes Exclusive	Overlap	3.16e-02	3.26e-02	1.19e-03	1.72e-03
BRCAgwas_GS Exclusive	Overlap	5.60e-02	4.70e-02	1.26e-02	1.83e-02
Overlap	Exclusives	1.59e-04	1.55e-08	4.94e-37	4.15e-22



Evaluating how well hg38_Reactome_genes genes are linked to BRCAgwas_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_Reactome_genes Exclusive	BRCAgwas_GS	0.61	0.98	1.80	1.73	5.07
BRCAgwas_GS Exclusive	hg38_Reactome_genes	0.66	1.15	1.78	1.58	6.09
hg38_Reactome_genes Exclusive	BRCAgwas_GS Exclusive	0.61	0.71	2.22	1.46	5.33
BRCAgwas_GS Exclusive	hg38_Reactome_genes Exclusive	0.65	1.32	1.79	1.27	6.16
hg38_Reactome_genes Exclusive	Overlap	0.95	2.30	2.36	2.82	3.10
BRCAgwas_GS Exclusive	Overlap	0.89	1.36	2.01	1.83	2.55
Overlap	Exclusives	0.69	2.98	7.09	2.52	12.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_Reactome_genes Exclusive	BRCAgwas_GS	0.01	0.11	1.67	2.23	6.62
BRCAgwas_GS Exclusive	hg38_Reactome_genes	0.01	1.05	3.07	2.43	4.44
hg38_Reactome_genes Exclusive	BRCAgwas_GS Exclusive	0.01	-0.54	1.47	1.43	4.07
BRCAgwas_GS Exclusive	hg38_Reactome_genes Exclusive	0.01	0.89	2.59	1.85	4.22
hg38_Reactome_genes Exclusive	Overlap	0.01	5.97	7.97	29.54	12.67
BRCAgwas_GS Exclusive	Overlap	0.00	3.99	14.78	11.77	9.29
Overlap	Exclusives	0.04	7.06	16.41	6.94	27.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
hg38_Reactome_genes Exclusive	144	140	MRM2;SLC8B1;MFSD4B;SPIDR
BRCAgwas_GS Exclusive	169	165	MRTFA;PIDD1;BORCS8;GATD1
Overlap	4	4