Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
hg38_EPI_genes	BRCAgwas_GS	7.04e-01	3.85e-01	2.41e-02	4.12e-03
BRCAgwas_GS	hg38_EPI_genes	3.41e-01	4.09e-01	9.30e-01	7.98e-02



Evaluating how well hg38_EPI_genes genes are linked to BRCAgwas_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_EPI_genes	BRCAgwas_GS	0.55	-0.84	-1.08	-1.44	2.26
BRCAgwas_GS	hg38_EPI_genes	0.45	-0.42	-1.28	-1.02	-1.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_EPI_genes	BRCAgwas_GS	0.01	-0.60	-0.66	-1.24	0.83
BRCAgwas_GS	hg38_EPI_genes	0.00	-0.36	-0.56	-0.92	-1.43

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
hg38_EPI_genes	95	91	AK9;KLHL40;MRM3;TMEM262
BRCAgwas_GS	173	169	BORCS8;MRTFA;PIDD1;GATD1