Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
hg38_EAML_genes Exclusive	BRCAgwas_GS	8.89e-01	6.33e-01	2.40e-01	2.10e-04
BRCAgwas_GS Exclusive	hg38_EAML_genes	3.68e-01	5.43e-01	1.13e-01	4.89e-01
hg38_EAML_genes Exclusive	BRCAgwas_GS Exclusive	8.96e-01	6.28e-01	3.33e-01	8.29e-05
BRCAgwas_GS Exclusive	hg38_EAML_genes Exclusive	4.18e-01	7.03e-01	1.94e-01	6.74e-01
hg38_EAML_genes Exclusive	Overlap	4.00e-01	3.67e-01	2.52e-01	2.78e-01
BRCAgwas_GS Exclusive	Overlap	9.92e-02	1.33e-01	9.92e-02	1.49e-01
Overlap	Exclusives	1.89e-02	5.30e-03	7.54e-18	2.86e-07



Evaluating how well hg38_EAML_genes genes are linked to BRCAgwas_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_EAML_genes Exclusive	BRCAgwas_GS	0.60	0.74	1.05	1.16	4.90
BRCAgwas_GS Exclusive	hg38_EAML_genes	0.51	-0.27	-0.39	0.27	0.43
hg38_EAML_genes Exclusive	BRCAgwas_GS Exclusive	0.60	0.62	1.03	0.96	4.77
BRCAgwas_GS Exclusive	hg38_EAML_genes Exclusive	0.51	-0.35	-0.53	0.36	0.30
hg38_EAML_genes Exclusive	Overlap	0.84	0.83	0.88	1.12	0.94
BRCAgwas_GS Exclusive	Overlap	0.96	1.56	1.31	1.73	1.53
Overlap	Exclusives	0.62	2.23	3.72	1.99	6.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_EAML_genes Exclusive	BRCAgwas_GS	0.01	1.04	1.23	1.52	2.32
BRCAgwas_GS Exclusive	hg38_EAML_genes	0.01	1.75	1.71	1.87	1.95
hg38_EAML_genes Exclusive	BRCAgwas_GS Exclusive	0.01	0.88	1.34	1.14	4.30
BRCAgwas_GS Exclusive	hg38_EAML_genes Exclusive	0.01	1.72	1.82	1.92	1.79
hg38_EAML_genes Exclusive	Overlap	0.00	-0.02	0.29	-0.00	-0.16
BRCAgwas_GS Exclusive	Overlap	0.00	3.07	1.87	4.12	-0.01
Overlap	Exclusives	0.02	2.66	5.72	2.47	8.50

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
hg38_EAML_genes Exclusive	80	76	FAM217A;LOC100130705;CYP3A7-CYP3A51P;CENPC
BRCAgwas_GS Exclusive	172	168	MRTFA;BORCS8;GATD1;PIDD1
Overlap	1	1