Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
hg38_top72_genes Exclusive	BRCAfamilial_GS	4.18e-10	8.65e-10	4.30e-14	1.21e-17
BRCAfamilial_GS Exclusive	hg38_top72_genes	3.74e-04	1.94e-03	1.19e-07	1.30e-03
hg38_top72_genes Exclusive	BRCAfamilial_GS Exclusive	1.44e-05	7.28e-06	2.25e-08	1.29e-12
BRCAfamilial_GS Exclusive	hg38_top72_genes Exclusive	6.58e-02	1.56e-01	9.92e-08	3.37e-02
hg38_top72_genes Exclusive	Overlap	5.61e-07	3.30e-07	4.71e-07	7.62e-07
BRCAfamilial_GS Exclusive	Overlap	3.30e-07	3.30e-07	3.30e-07	3.61e-07
Overlap	Exclusives	9.64e-07	2.46e-06	2.16e-10	1.64e-10



Evaluating how well hg38_top72_genes genes are linked to BRCAfamilial_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_top72_genes Exclusive	BRCAfamilial_GS	0.95	3.26	7.25	3.15	8.76
BRCAfamilial_GS Exclusive	hg38_top72_genes	0.64	3.36	1.97	1.89	4.39
hg38_top72_genes Exclusive	BRCAfamilial_GS Exclusive	0.94	2.59	6.13	2.69	7.32
BRCAfamilial_GS Exclusive	hg38_top72_genes Exclusive	0.60	2.19	1.01	1.35	2.66
hg38_top72_genes Exclusive	Overlap	0.99	3.01	4.95	2.95	4.56
BRCAfamilial_GS Exclusive	Overlap	1.00	3.67	5.22	3.00	4.59
Overlap	Exclusives	0.72	5.21	4.10	3.15	6.92

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_top72_genes Exclusive	BRCAfamilial_GS	0.02	12.78	34.24	14.61	32.80
BRCAfamilial_GS Exclusive	hg38_top72_genes	0.05	44.58	78.57	60.46	69.13
hg38_top72_genes Exclusive	BRCAfamilial_GS Exclusive	0.01	4.88	16.61	6.57	14.08
BRCAfamilial_GS Exclusive	hg38_top72_genes Exclusive	0.01	5.52	7.99	7.46	8.73
hg38_top72_genes Exclusive	Overlap	0.02	21.85	85.72	13.25	4.10
BRCAfamilial_GS Exclusive	Overlap	0.33	435.95	1262.47	513.75	593.22
Overlap	Exclusives	0.04	42.55	50.78	22.86	69.59

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
hg38_top72_genes Exclusive	65	64	MRM2
BRCAfamilial_GS Exclusive	24	24	
Overlap	7	7