Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
hg38_top72_genes Exclusive	BRCAgwasERpos_GS	1.25e-01	2.15e-02	4.37e-03	3.32e-04
BRCAgwasERpos_GS Exclusive	hg38_top72_genes	3.42e-01	2.85e-01	1.67e-01	1.89e-02
hg38_top72_genes Exclusive	BRCAgwasERpos_GS Exclusive	1.70e-01	3.74e-02	1.69e-03	5.27e-04
BRCAgwasERpos_GS Exclusive	hg38_top72_genes Exclusive	2.85e-01	2.19e-01	1.12e-01	1.74e-02
hg38_top72_genes Exclusive	Overlap	2.52e-01	4.91e-01	2.06e-01	2.17e-01
BRCAgwasERpos_GS Exclusive	Overlap	8.47e-01	5.50e-01	7.93e-01	8.11e-01
Overlap	Exclusives	1.06e-01	4.29e-02	1.07e-04	2.10e-04



Evaluating how well hg38_top72_genes genes are linked to BRCAgwasERpos_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_top72_genes Exclusive	BRCAgwasERpos_GS	0.61	2.24	1.85	1.98	2.94
BRCAgwasERpos_GS Exclusive	hg38_top72_genes	0.59	0.46	0.09	0.25	2.94
hg38_top72_genes Exclusive	BRCAgwasERpos_GS Exclusive	0.61	2.53	2.17	2.01	2.78
BRCAgwasERpos_GS Exclusive	hg38_top72_genes Exclusive	0.59	0.44	0.31	0.49	2.86
hg38_top72_genes Exclusive	Overlap	0.81	1.18	0.79	1.03	1.18
BRCAgwasERpos_GS Exclusive	Overlap	0.51	-0.27	-0.49	-0.49	0.04
Overlap	Exclusives	0.60	0.52	1.58	0.86	4.11

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_top72_genes Exclusive	BRCAgwasERpos_GS	0.00	1.36	0.34	1.12	2.94
BRCAgwasERpos_GS Exclusive	hg38_top72_genes	0.01	0.65	2.43	0.59	0.81
hg38_top72_genes Exclusive	BRCAgwasERpos_GS Exclusive	0.00	0.31	1.60	1.68	3.18
BRCAgwasERpos_GS Exclusive	hg38_top72_genes Exclusive	0.01	1.43	2.19	0.76	4.86
hg38_top72_genes Exclusive	Overlap	0.00	-0.01	0.33	-0.08	-0.03
BRCAgwasERpos_GS Exclusive	Overlap	0.00	-0.40	-0.58	-0.31	-0.31
Overlap	Exclusives	0.01	0.90	2.40	0.85	4.99

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
hg38_top72_genes Exclusive	71	70	MRM2
BRCAgwasERpos_GS Exclusive	59	59	
Overlap	1	1