Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
hg38_top72_genes Exclusive	BRCAgwasERneutral_GS	9.31e-01	6.28e-01	3.72e-02	5.93e-04
BRCAgwasERneutral_GS Exclusive	hg38_top72_genes	5.48e-01	5.44e-01	2.28e-02	5.34e-02
hg38_top72_genes Exclusive	BRCAgwasERneutral_GS Exclusive	9.23e-01	6.58e-01	5.95e-02	1.00e-03
BRCAgwasERneutral_GS Exclusive	hg38_top72_genes Exclusive	4.94e-01	5.05e-01	4.38e-02	4.23e-02
hg38_top72_genes Exclusive	Overlap	1.66e-01	4.72e-01	1.66e-01	1.75e-01
BRCAgwasERneutral_GS Exclusive	Overlap	3.51e-01	4.17e-01	1.75e-01	1.75e-01
Overlap	Exclusives	1.27e-02	7.73e-03	2.36e-13	3.48e-07



Evaluating how well hg38_top72_genes genes are linked to BRCAgwasERneutral_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_top72_genes Exclusive	BRCAgwasERneutral_GS	0.63	0.70	0.67	0.99	3.84
BRCAgwasERneutral_GS Exclusive	hg38_top72_genes	0.59	-0.29	-0.19	0.53	2.67
hg38_top72_genes Exclusive	BRCAgwasERneutral_GS Exclusive	0.62	0.68	0.57	0.66	3.74
BRCAgwasERneutral_GS Exclusive	hg38_top72_genes Exclusive	0.59	-0.46	-0.09	0.26	2.72
hg38_top72_genes Exclusive	Overlap	0.89	1.52	0.52	1.18	1.43
BRCAgwasERneutral_GS Exclusive	Overlap	0.85	0.80	0.66	1.13	1.43
Overlap	Exclusives	0.64	0.76	1.93	1.67	7.08

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_top72_genes Exclusive	BRCAgwasERneutral_GS	0.01	0.05	-0.16	0.77	0.61
BRCAgwasERneutral_GS Exclusive	hg38_top72_genes	0.01	0.03	0.91	1.26	2.24
hg38_top72_genes Exclusive	BRCAgwasERneutral_GS Exclusive	0.01	0.15	-0.21	0.55	0.69
BRCAgwasERneutral_GS Exclusive	hg38_top72_genes Exclusive	0.01	-0.21	0.98	0.27	2.63
hg38_top72_genes Exclusive	Overlap	0.00	0.44	-0.52	0.32	0.26
BRCAgwasERneutral_GS Exclusive	Overlap	0.00	-0.11	-0.23	0.20	-0.07
Overlap	Exclusives	0.01	0.39	2.62	2.20	8.04

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
hg38_top72_genes Exclusive	71	70	MRM2
BRCAgwasERneutral_GS Exclusive	75	71	GATD1;MRTFA;BORCS8;PIDD1
Overlap	1	1