Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
hg38_STRING_genes Exclusive	BRCAgwasERneutral_GS	4.64e-03	2.52e-01	6.91e-02	1.41e-01
BRCAgwasERneutral_GS Exclusive	hg38_STRING_genes	1.04e-01	1.03e-01	1.16e-03	4.25e-01
hg38_STRING_genes Exclusive	BRCAgwasERneutral_GS Exclusive	1.39e-02	2.77e-01	1.04e-01	2.11e-01
BRCAgwasERneutral_GS Exclusive	hg38_STRING_genes Exclusive	8.87e-02	8.30e-02	2.28e-03	3.13e-01
hg38_STRING_genes Exclusive	Overlap	1.33e-01	6.31e-01	3.35e-01	6.73e-01
BRCAgwasERneutral_GS Exclusive	Overlap	4.72e-01	4.35e-01	1.33e-01	2.28e-01
Overlap	Exclusives	4.49e-02	8.62e-01	1.28e-16	1.82e-03



Evaluating how well hg38_STRING_genes genes are linked to BRCAgwasERneutral_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_STRING_genes Exclusive	BRCAgwasERneutral_GS	0.55	-2.93	-2.22	-2.01	1.30
BRCAgwasERneutral_GS Exclusive	hg38_STRING_genes	0.51	-2.03	-2.87	-1.01	0.31
hg38_STRING_genes Exclusive	BRCAgwasERneutral_GS Exclusive	0.55	-2.52	-2.17	-1.72	1.35
BRCAgwasERneutral_GS Exclusive	hg38_STRING_genes Exclusive	0.51	-1.92	-3.50	-1.13	0.36
hg38_STRING_genes Exclusive	Overlap	0.49	-1.30	-0.63	-0.77	0.15
BRCAgwasERneutral_GS Exclusive	Overlap	0.85	0.69	0.62	1.39	1.28
Overlap	Exclusives	0.57	-0.31	-0.21	0.43	4.25

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_STRING_genes Exclusive	BRCAgwasERneutral_GS	0.00	-1.60	-0.69	-0.65	0.44
BRCAgwasERneutral_GS Exclusive	hg38_STRING_genes	0.01	-1.64	-2.35	-0.99	-0.93
hg38_STRING_genes Exclusive	BRCAgwasERneutral_GS Exclusive	0.00	-1.53	-0.72	-0.56	1.09
BRCAgwasERneutral_GS Exclusive	hg38_STRING_genes Exclusive	0.01	-1.42	-2.50	-1.13	-0.89
hg38_STRING_genes Exclusive	Overlap	0.00	-0.52	-0.51	-0.43	-0.20
BRCAgwasERneutral_GS Exclusive	Overlap	0.00	-0.16	-0.27	-0.03	0.09
Overlap	Exclusives	0.02	-0.16	0.07	0.38	3.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
hg38_STRING_genes Exclusive	210	200	MALRD1;CFAP45;ETFBKMT;PADI6;VPS11;WHRN;MRM2;MFSD13A;STPG2;KRBOX4
BRCAgwasERneutral_GS Exclusive	75	71	GATD1;PIDD1;MRTFA;BORCS8
Overlap	1	1