Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
hg38_Reactome_genes Exclusive	BRCAgwasERpos_GS	5.72e-02	1.07e-01	1.94e-03	6.11e-03
BRCAgwasERpos_GS Exclusive	hg38_Reactome_genes	1.13e-02	1.93e-02	1.15e-04	8.15e-09
hg38_Reactome_genes Exclusive	BRCAgwasERpos_GS Exclusive	1.09e-01	1.00e-01	4.56e-03	1.72e-02
BRCAgwasERpos_GS Exclusive	hg38_Reactome_genes Exclusive	1.10e-02	2.92e-02	2.90e-05	2.40e-09
hg38_Reactome_genes Exclusive	Overlap	9.92e-02	2.78e-01	1.05e-01	1.33e-01
BRCAgwasERpos_GS Exclusive	Overlap	8.29e-01	7.14e-01	8.29e-01	7.34e-01
Overlap	Exclusives	3.54e-04	1.39e-03	1.65e-19	5.27e-13



Evaluating how well hg38_Reactome_genes genes are linked to BRCAgwasERpos_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_Reactome_genes Exclusive	BRCAgwasERpos_GS	0.62	2.64	2.49	2.28	3.27
BRCAgwasERpos_GS Exclusive	hg38_Reactome_genes	0.67	1.98	2.98	1.56	7.45
hg38_Reactome_genes Exclusive	BRCAgwasERpos_GS Exclusive	0.61	1.89	2.29	2.16	2.81
BRCAgwasERpos_GS Exclusive	hg38_Reactome_genes Exclusive	0.67	1.84	2.93	1.69	7.34
hg38_Reactome_genes Exclusive	Overlap	0.91	1.68	1.02	1.69	1.51
BRCAgwasERpos_GS Exclusive	Overlap	0.51	-0.29	-0.31	-0.45	0.08
Overlap	Exclusives	0.67	1.33	4.87	1.67	8.45

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_Reactome_genes Exclusive	BRCAgwasERpos_GS	0.01	2.12	3.04	2.88	3.17
BRCAgwasERpos_GS Exclusive	hg38_Reactome_genes	0.02	4.05	7.68	3.22	11.22
hg38_Reactome_genes Exclusive	BRCAgwasERpos_GS Exclusive	0.01	1.06	3.02	2.99	4.07
BRCAgwasERpos_GS Exclusive	hg38_Reactome_genes Exclusive	0.02	3.73	6.49	3.50	7.74
hg38_Reactome_genes Exclusive	Overlap	0.00	2.56	-0.10	1.15	0.50
BRCAgwasERpos_GS Exclusive	Overlap	0.00	-0.27	-0.50	-0.38	-0.19
Overlap	Exclusives	0.02	0.64	4.84	1.60	6.68

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
hg38_Reactome_genes Exclusive	147	143	MFSD4B;SLC8B1;MRM2;SPIDR
BRCAgwasERpos_GS Exclusive	59	59	
Overlap	1	1