Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
hg38_Reactome_genes Exclusive	BRCAgwasERneg_GS	1.69e-01	1.49e-01	7.92e-03	1.44e-02
BRCAgwasERneg_GS Exclusive	hg38_Reactome_genes	6.95e-01	7.46e-01	5.30e-04	2.68e-08
hg38_Reactome_genes Exclusive	BRCAgwasERneg_GS Exclusive	2.06e-01	3.53e-01	1.79e-02	4.59e-02
BRCAgwasERneg_GS Exclusive	hg38_Reactome_genes Exclusive	6.61e-01	5.83e-01	5.95e-04	3.20e-08
hg38_Reactome_genes Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
BRCAgwasERneg_GS Exclusive	Overlap	1.22e-02	1.15e-02	1.15e-02	1.28e-02
Overlap	Exclusives	2.38e-05	6.84e-06	2.48e-36	3.73e-15



Evaluating how well hg38_Reactome_genes genes are linked to BRCAgwasERneg_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_Reactome_genes Exclusive	BRCAgwasERneg_GS	0.64	0.66	1.25	1.42	2.75
BRCAgwasERneg_GS Exclusive	hg38_Reactome_genes	0.64	0.13	0.17	0.45	5.71
hg38_Reactome_genes Exclusive	BRCAgwasERneg_GS Exclusive	0.62	0.69	0.97	1.04	2.23
BRCAgwasERneg_GS Exclusive	hg38_Reactome_genes Exclusive	0.63	0.19	0.25	0.34	5.75
hg38_Reactome_genes Exclusive	Overlap	1.00	1.66	2.07	1.88	2.19
BRCAgwasERneg_GS Exclusive	Overlap	0.98	2.57	2.50	2.48	2.51
Overlap	Exclusives	0.70	1.78	5.64	2.04	9.74

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_Reactome_genes Exclusive	BRCAgwasERneg_GS	0.00	0.56	2.98	2.43	0.56
BRCAgwasERneg_GS Exclusive	hg38_Reactome_genes	0.01	0.40	0.87	0.63	3.15
hg38_Reactome_genes Exclusive	BRCAgwasERneg_GS Exclusive	0.00	-0.43	0.47	0.24	1.76
BRCAgwasERneg_GS Exclusive	hg38_Reactome_genes Exclusive	0.01	0.34	0.63	0.36	4.78
hg38_Reactome_genes Exclusive	Overlap	0.02	2.66	47.22	23.91	45.83
BRCAgwasERneg_GS Exclusive	Overlap	0.00	13.39	22.48	18.47	0.36
Overlap	Exclusives	0.04	11.06	28.81	9.48	28.54

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
hg38_Reactome_genes Exclusive	146	142	SLC8B1;MFSD4B;SPIDR;MRM2
BRCAgwasERneg_GS Exclusive	35	35	
Overlap	2	2