Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
hg38_Reactome_genes Exclusive	BRCAgwasERneutral_GS	3.95e-02	4.52e-01	2.19e-01	5.70e-03
BRCAgwasERneutral_GS Exclusive	hg38_Reactome_genes	9.23e-01	8.12e-01	1.89e-04	1.13e-05
hg38_Reactome_genes Exclusive	BRCAgwasERneutral_GS Exclusive	6.63e-02	4.36e-01	2.11e-01	2.15e-02
BRCAgwasERneutral_GS Exclusive	hg38_Reactome_genes Exclusive	9.09e-01	8.45e-01	1.05e-03	1.85e-05
hg38_Reactome_genes Exclusive	Overlap	1.12e-01	1.49e-01	9.92e-02	1.12e-01
BRCAgwasERneutral_GS Exclusive	Overlap	3.20e-01	3.35e-01	1.12e-01	2.65e-01
Overlap	Exclusives	4.59e-05	7.77e-04	4.92e-21	8.18e-13



Evaluating how well hg38_Reactome_genes genes are linked to BRCAgwasERneutral_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_Reactome_genes Exclusive	BRCAgwasERneutral_GS	0.60	-1.23	-0.18	0.15	3.26
BRCAgwasERneutral_GS Exclusive	hg38_Reactome_genes	0.62	-0.25	-0.54	0.19	4.77
hg38_Reactome_genes Exclusive	BRCAgwasERneutral_GS Exclusive	0.60	-0.87	-0.13	0.12	2.78
BRCAgwasERneutral_GS Exclusive	hg38_Reactome_genes Exclusive	0.62	-0.25	-0.42	0.02	5.05
hg38_Reactome_genes Exclusive	Overlap	0.95	1.47	0.93	1.60	1.80
BRCAgwasERneutral_GS Exclusive	Overlap	0.85	0.80	0.65	1.44	1.12
Overlap	Exclusives	0.67	0.92	3.73	1.18	10.11

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_Reactome_genes Exclusive	BRCAgwasERneutral_GS	0.01	-1.67	-0.44	-0.08	2.28
BRCAgwasERneutral_GS Exclusive	hg38_Reactome_genes	0.01	-0.67	-0.73	0.02	1.64
hg38_Reactome_genes Exclusive	BRCAgwasERneutral_GS Exclusive	0.00	-1.57	-0.51	-0.09	2.02
BRCAgwasERneutral_GS Exclusive	hg38_Reactome_genes Exclusive	0.01	-0.65	-0.63	-0.10	3.07
hg38_Reactome_genes Exclusive	Overlap	0.00	0.14	0.64	1.86	1.71
BRCAgwasERneutral_GS Exclusive	Overlap	0.00	-0.13	-0.26	1.25	-0.12
Overlap	Exclusives	0.02	1.23	5.72	2.01	13.44

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
hg38_Reactome_genes Exclusive	147	143	SLC8B1;MRM2;SPIDR;MFSD4B
BRCAgwasERneutral_GS Exclusive	75	71	PIDD1;MRTFA;BORCS8;GATD1
Overlap	1	1