Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
hg38_Wavelet_genes Exclusive	BRCAgwasERpos_GS	7.17e-01	7.66e-01	5.21e-06	1.40e-01
BRCAgwasERpos_GS Exclusive	hg38_Wavelet_genes	4.65e-02	1.77e-01	2.34e-03	1.49e-19
hg38_Wavelet_genes Exclusive	BRCAgwasERpos_GS Exclusive	7.03e-01	7.14e-01	1.05e-05	1.77e-01
BRCAgwasERpos_GS Exclusive	hg38_Wavelet_genes Exclusive	4.90e-02	2.25e-01	3.83e-03	1.09e-19
hg38_Wavelet_genes Exclusive	Overlap	5.40e-01	9.60e-01	5.40e-01	1.28e-01
BRCAgwasERpos_GS Exclusive	Overlap	5.40e-01	5.40e-01	5.40e-01	2.04e-01
Overlap	Exclusives	1.51e-02	3.05e-04	1.08e-63	1.50e-27



Evaluating how well hg38_Wavelet_genes genes are linked to BRCAgwasERpos_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_Wavelet_genes Exclusive	BRCAgwasERpos_GS	0.59	1.00	1.90	1.37	2.42
BRCAgwasERpos_GS Exclusive	hg38_Wavelet_genes	0.72	-0.01	1.10	0.93	9.88
hg38_Wavelet_genes Exclusive	BRCAgwasERpos_GS Exclusive	0.58	0.86	1.37	1.45	2.31
BRCAgwasERpos_GS Exclusive	hg38_Wavelet_genes Exclusive	0.72	-0.05	0.91	0.82	10.29
hg38_Wavelet_genes Exclusive	Overlap	0.86	1.07	0.47	0.59	1.83
BRCAgwasERpos_GS Exclusive	Overlap	0.85	0.67	0.87	1.21	1.76
Overlap	Exclusives	0.73	1.33	5.43	1.75	11.69

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_Wavelet_genes Exclusive	BRCAgwasERpos_GS	0.01	2.13	1.99	4.57	5.72
BRCAgwasERpos_GS Exclusive	hg38_Wavelet_genes	0.02	1.44	2.26	2.27	10.66
hg38_Wavelet_genes Exclusive	BRCAgwasERpos_GS Exclusive	0.00	1.28	1.32	3.38	2.57
BRCAgwasERpos_GS Exclusive	hg38_Wavelet_genes Exclusive	0.02	0.82	1.59	1.69	14.30
hg38_Wavelet_genes Exclusive	Overlap	0.01	3.21	0.33	18.39	25.09
BRCAgwasERpos_GS Exclusive	Overlap	0.01	21.10	29.90	47.10	55.99
Overlap	Exclusives	0.03	1.29	6.90	1.84	12.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
hg38_Wavelet_genes Exclusive	162	161	RNASE12
BRCAgwasERpos_GS Exclusive	58	58	
Overlap	2	2