Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
hg38_Wavelet_genes Exclusive	BRCAgwasERneg_GS	8.76e-01	2.88e-01	3.27e-05	1.19e-02
BRCAgwasERneg_GS Exclusive	hg38_Wavelet_genes	1.09e-01	2.95e-01	1.78e-04	5.23e-27
hg38_Wavelet_genes Exclusive	BRCAgwasERneg_GS Exclusive	9.57e-01	2.81e-01	1.14e-04	6.94e-02
BRCAgwasERneg_GS Exclusive	hg38_Wavelet_genes Exclusive	1.99e-01	3.39e-01	2.74e-04	2.38e-25
hg38_Wavelet_genes Exclusive	Overlap	6.74e-01	7.54e-01	1.42e-02	2.10e-02
BRCAgwasERneg_GS Exclusive	Overlap	1.35e-02	1.15e-02	1.35e-02	1.35e-02
Overlap	Exclusives	3.82e-02	1.47e-02	2.31e-67	6.50e-24



Evaluating how well hg38_Wavelet_genes genes are linked to BRCAgwasERneg_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_Wavelet_genes Exclusive	BRCAgwasERneg_GS	0.63	0.10	0.16	1.34	3.03
BRCAgwasERneg_GS Exclusive	hg38_Wavelet_genes	0.74	0.75	1.84	1.41	11.63
hg38_Wavelet_genes Exclusive	BRCAgwasERneg_GS Exclusive	0.61	0.06	0.02	0.95	2.13
BRCAgwasERneg_GS Exclusive	hg38_Wavelet_genes Exclusive	0.74	0.39	1.86	1.52	10.48
hg38_Wavelet_genes Exclusive	Overlap	0.98	1.15	1.27	1.28	2.16
BRCAgwasERneg_GS Exclusive	Overlap	0.99	2.03	2.89	2.17	2.28
Overlap	Exclusives	0.74	-1.43	3.22	1.33	11.44

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_Wavelet_genes Exclusive	BRCAgwasERneg_GS	0.01	5.69	7.34	6.15	7.46
BRCAgwasERneg_GS Exclusive	hg38_Wavelet_genes	0.02	1.85	3.15	3.03	14.08
hg38_Wavelet_genes Exclusive	BRCAgwasERneg_GS Exclusive	0.00	7.88	7.29	4.58	7.50
BRCAgwasERneg_GS Exclusive	hg38_Wavelet_genes Exclusive	0.02	1.26	2.78	2.88	8.62
hg38_Wavelet_genes Exclusive	Overlap	0.00	0.32	1.07	1.62	4.00
BRCAgwasERneg_GS Exclusive	Overlap	0.00	7.73	17.98	12.14	17.75
Overlap	Exclusives	0.02	0.71	4.19	1.45	14.92

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
hg38_Wavelet_genes Exclusive	162	161	RNASE12
BRCAgwasERneg_GS Exclusive	35	35	
Overlap	2	2