Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
hg38_EPI_genes	BRCAgwasERpos_GS	5.23e-01	2.62e-01	9.59e-02	5.74e-01
BRCAgwasERpos_GS	hg38_EPI_genes	4.08e-01	4.16e-01	6.15e-01	1.73e-01



Evaluating how well hg38_EPI_genes genes are linked to BRCAgwasERpos_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_EPI_genes	BRCAgwasERpos_GS	0.51	-1.00	-1.39	-1.17	0.09
BRCAgwasERpos_GS	hg38_EPI_genes	0.45	-1.05	-1.18	-1.07	-1.63

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_EPI_genes	BRCAgwasERpos_GS	0.00	-0.75	-1.00	-0.85	-0.25
BRCAgwasERpos_GS	hg38_EPI_genes	0.00	-0.71	-0.58	-0.50	-0.66

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
hg38_EPI_genes	95	91	KLHL40;MRM3;TMEM262;AK9
BRCAgwasERpos_GS	60	60