Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
hg38_EPI_genes	BRCAgwasERneg_GS	8.70e-01	9.03e-01	5.10e-01	3.27e-01
BRCAgwasERneg_GS	hg38_EPI_genes	6.69e-01	6.53e-01	5.30e-02	2.14e-01



Evaluating how well hg38_EPI_genes genes are linked to BRCAgwasERneg_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_EPI_genes	BRCAgwasERneg_GS	0.54	-0.72	-0.61	-0.99	0.98
BRCAgwasERneg_GS	hg38_EPI_genes	0.46	-0.29	-0.99	-1.00	-1.45

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_EPI_genes	BRCAgwasERneg_GS	0.00	-0.80	-0.35	-0.94	-0.17
BRCAgwasERneg_GS	hg38_EPI_genes	0.00	-0.22	-0.60	-1.08	-1.24

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
hg38_EPI_genes	95	91	KLHL40;AK9;MRM3;TMEM262
BRCAgwasERneg_GS	37	37