Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
hg38_EPI_genes	BRCAgwasERneutral_GS	8.31e-01	7.36e-01	2.02e-01	1.17e-02
BRCAgwasERneutral_GS	hg38_EPI_genes	6.76e-01	5.11e-01	1.30e-02	8.47e-02



Evaluating how well hg38_EPI_genes genes are linked to BRCAgwasERneutral_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_EPI_genes	BRCAgwasERneutral_GS	0.59	-0.25	0.29	-0.34	2.76
BRCAgwasERneutral_GS	hg38_EPI_genes	0.47	0.52	-0.36	-0.25	-1.12

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_EPI_genes	BRCAgwasERneutral_GS	0.00	0.13	0.61	-0.13	1.90
BRCAgwasERneutral_GS	hg38_EPI_genes	0.01	1.87	1.65	0.29	0.24

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
hg38_EPI_genes	95	91	TMEM262;MRM3;KLHL40;AK9
BRCAgwasERneutral_GS	76	72	MRTFA;BORCS8;PIDD1;GATD1