Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
hg38_EAML_genes	BRCAgwasERneg_GS	4.83e-01	1.95e-01	4.73e-01	1.00e-01
BRCAgwasERneg_GS	hg38_EAML_genes	6.38e-01	8.50e-01	4.49e-02	4.45e-01



Evaluating how well hg38_EAML_genes genes are linked to BRCAgwasERneg_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_EAML_genes	BRCAgwasERneg_GS	0.61	0.81	1.00	0.61	2.00
BRCAgwasERneg_GS	hg38_EAML_genes	0.52	0.59	-0.01	0.51	0.64

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_EAML_genes	BRCAgwasERneg_GS	0.00	0.54	0.46	0.48	0.03
BRCAgwasERneg_GS	hg38_EAML_genes	0.00	0.87	0.51	0.55	0.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
hg38_EAML_genes	81	77	CYP3A7-CYP3A51P;CENPC;FAM217A;LOC100130705
BRCAgwasERneg_GS	37	37