Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
hg38_EAML_genes	BRCAgwasERneutral_GS	7.67e-01	4.40e-01	2.52e-01	8.67e-04
BRCAgwasERneutral_GS	hg38_EAML_genes	4.57e-01	7.95e-01	5.45e-02	5.09e-01



Evaluating how well hg38_EAML_genes genes are linked to BRCAgwasERneutral_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_EAML_genes	BRCAgwasERneutral_GS	0.64	0.90	1.60	1.26	4.25
BRCAgwasERneutral_GS	hg38_EAML_genes	0.52	0.09	-0.11	0.53	0.80

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
hg38_EAML_genes	BRCAgwasERneutral_GS	0.01	1.78	2.04	2.01	1.31
BRCAgwasERneutral_GS	hg38_EAML_genes	0.01	3.07	3.06	3.05	3.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
hg38_EAML_genes	81	77	CYP3A7-CYP3A51P;FAM217A;LOC100130705;CENPC
BRCAgwasERneutral_GS	76	72	PIDD1;BORCS8;GATD1;MRTFA