Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAReactome Exclusive	GWASCatalog	3.90e-04	1.81e-02	1.06e-02	8.01e-06
GWASCatalog Exclusive	EAReactome	7.95e-03	3.45e-02	2.08e-13	9.14e-09
EAReactome Exclusive	GWASCatalog Exclusive	3.66e-04	2.36e-02	3.24e-02	4.62e-05
GWASCatalog Exclusive	EAReactome Exclusive	3.70e-04	1.84e-02	2.04e-13	1.29e-08
EAReactome Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.57e-02
GWASCatalog Exclusive	Overlap	3.72e-01	4.40e-01	9.05e-02	4.23e-02
Overlap	Exclusives	3.10e-64	1.62e-88	5.68e-167	4.45e-112



Evaluating how well EAReactome genes are linked to GWASCatalog genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAReactome Exclusive	GWASCatalog	0.67	0.90	2.57	1.30	4.70
GWASCatalog Exclusive	EAReactome	0.59	1.31	2.12	0.82	5.19
EAReactome Exclusive	GWASCatalog Exclusive	0.66	0.81	2.61	1.13	4.77
GWASCatalog Exclusive	EAReactome Exclusive	0.59	1.61	1.92	0.85	5.60
EAReactome Exclusive	Overlap	0.98	1.60	1.65	2.20	2.74
GWASCatalog Exclusive	Overlap	0.92	1.66	1.25	1.68	2.06
Overlap	Exclusives	0.85	2.69	23.92	2.83	24.74

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAReactome Exclusive	GWASCatalog	0.01	0.04	2.87	1.09	5.42
GWASCatalog Exclusive	EAReactome	0.02	2.08	3.94	1.38	5.67
EAReactome Exclusive	GWASCatalog Exclusive	0.01	-0.60	-0.04	0.31	3.34
GWASCatalog Exclusive	EAReactome Exclusive	0.02	1.87	2.86	0.94	4.63
EAReactome Exclusive	Overlap	0.00	6.19	14.33	10.32	2.37
GWASCatalog Exclusive	Overlap	0.02	45.66	54.21	70.95	87.92
Overlap	Exclusives	0.09	9.81	61.55	5.61	74.55

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAReactome Exclusive	307	306	UGT2A1
GWASCatalog Exclusive	68	67	ODZ3
Overlap	2	2