Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA_STRING Exclusive	GWASCatalog	6.42e-03	3.98e-01	5.53e-03	1.33e-03
GWASCatalog Exclusive	EA_STRING	1.70e-01	2.13e-01	5.60e-10	3.22e-04
EA_STRING Exclusive	GWASCatalog Exclusive	3.96e-03	4.95e-01	3.25e-03	1.03e-02
GWASCatalog Exclusive	EA_STRING Exclusive	1.20e-01	1.89e-01	4.53e-10	3.25e-04
EA_STRING Exclusive	Overlap	1.14e-02	2.30e-02	1.02e-02	5.75e-03
GWASCatalog Exclusive	Overlap	1.02e-02	1.02e-02	1.02e-02	1.02e-02
Overlap	Exclusives	3.46e-19	9.55e-19	1.74e-88	3.28e-18



Evaluating how well EA_STRING genes are linked to GWASCatalog genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA_STRING Exclusive	GWASCatalog	0.62	-0.53	0.85	-1.24	3.37
GWASCatalog Exclusive	EA_STRING	0.51	1.20	0.42	0.46	0.32
EA_STRING Exclusive	GWASCatalog Exclusive	0.60	-1.44	-0.02	-1.49	2.94
GWASCatalog Exclusive	EA_STRING Exclusive	0.50	1.26	0.23	0.15	0.04
EA_STRING Exclusive	Overlap	0.93	2.71	2.75	2.76	3.14
GWASCatalog Exclusive	Overlap	0.92	2.57	2.39	2.62	2.49
Overlap	Exclusives	0.62	2.75	12.24	2.92	9.52

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA_STRING Exclusive	GWASCatalog	0.01	0.43	0.27	-0.16	1.19
GWASCatalog Exclusive	EA_STRING	0.03	1.05	0.20	0.16	-0.57
EA_STRING Exclusive	GWASCatalog Exclusive	0.01	-0.88	-0.07	-1.06	2.45
GWASCatalog Exclusive	EA_STRING Exclusive	0.03	0.84	-0.78	-0.53	-1.45
EA_STRING Exclusive	Overlap	0.00	8.33	8.40	11.83	8.04
GWASCatalog Exclusive	Overlap	0.07	107.76	114.61	235.96	192.89
Overlap	Exclusives	0.07	7.66	30.21	6.98	27.04

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA_STRING Exclusive	613	607	UGT2A1;MRPL23;ZNF816-ZNF321P;PTGES3L-AARSD1;GIMAP1-GIMAP5;PAGR1
GWASCatalog Exclusive	66	65	ODZ3
Overlap	4	4