Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA_ML Exclusive	GWASCatalog	7.09e-01	2.77e-01	7.61e-01	3.94e-03
GWASCatalog Exclusive	EA_ML	3.29e-01	1.48e-01	9.96e-04	3.22e-01
EA_ML Exclusive	GWASCatalog Exclusive	5.27e-01	2.71e-01	9.94e-01	3.00e-03
GWASCatalog Exclusive	EA_ML Exclusive	4.14e-01	1.58e-01	5.29e-03	2.12e-01
EA_ML Exclusive	Overlap	4.90e-01	5.25e-01	2.57e-01	9.65e-01
GWASCatalog Exclusive	Overlap	1.69e-04	1.69e-04	1.69e-04	1.69e-04
Overlap	Exclusives	1.99e-05	1.95e-05	8.65e-15	7.77e-06



Evaluating how well EA_ML genes are linked to GWASCatalog genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA_ML Exclusive	GWASCatalog	0.61	0.80	1.34	0.21	2.84
GWASCatalog Exclusive	EA_ML	0.51	1.21	1.18	0.83	0.46
EA_ML Exclusive	GWASCatalog Exclusive	0.62	0.92	1.59	0.64	3.48
GWASCatalog Exclusive	EA_ML Exclusive	0.49	1.08	0.68	0.20	-0.39
EA_ML Exclusive	Overlap	0.52	-1.27	-0.69	-1.75	0.02
GWASCatalog Exclusive	Overlap	1.00	3.53	3.35	3.37	3.33
Overlap	Exclusives	0.60	2.67	4.73	2.64	4.54

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA_ML Exclusive	GWASCatalog	0.00	0.53	0.70	-0.11	1.40
GWASCatalog Exclusive	EA_ML	0.02	34.51	26.71	12.01	23.89
EA_ML Exclusive	GWASCatalog Exclusive	0.00	0.64	0.96	0.25	2.29
GWASCatalog Exclusive	EA_ML Exclusive	0.01	0.51	0.56	-0.15	-0.27
EA_ML Exclusive	Overlap	0.00	-0.83	-0.56	-0.61	-0.13
GWASCatalog Exclusive	Overlap	0.36	453.25	663.36	852.34	751.00
Overlap	Exclusives	0.05	36.95	67.18	34.16	61.97

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA_ML Exclusive	107	106	ZNF23
GWASCatalog Exclusive	66	65	ODZ3
Overlap	4	4