Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
overlap Exclusive	Nelson_validated	3.03e-06	2.33e-04	1.91e-07	4.49e-07
Nelson_validated Exclusive	overlap	3.27e-08	1.92e-07	1.06e-12	5.82e-13
overlap Exclusive	Nelson_validated Exclusive	4.49e-05	7.45e-04	1.97e-06	1.39e-06
Nelson_validated Exclusive	overlap Exclusive	1.10e-06	6.10e-07	1.44e-11	2.00e-11
overlap Exclusive	Overlap	7.08e-02	1.00e-01	6.77e-02	1.09e-01
Nelson_validated Exclusive	Overlap	1.64e-04	1.64e-04	1.64e-04	1.77e-04
Overlap	Exclusives	2.49e-19	8.51e-19	2.26e-56	1.02e-36



Evaluating how well overlap genes are linked to Nelson_validated genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
overlap Exclusive	Nelson_validated	0.72	2.78	5.08	2.39	7.07
Nelson_validated Exclusive	overlap	0.71	3.09	6.72	2.73	8.59
overlap Exclusive	Nelson_validated Exclusive	0.71	3.00	4.97	3.12	6.23
Nelson_validated Exclusive	overlap Exclusive	0.70	2.79	6.85	3.23	7.68
overlap Exclusive	Overlap	0.74	0.43	1.07	0.88	2.09
Nelson_validated Exclusive	Overlap	0.92	3.46	3.18	3.15	3.71
Overlap	Exclusives	0.78	3.27	13.74	2.93	13.86

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
overlap Exclusive	Nelson_validated	0.01	5.21	5.70	6.94	11.58
Nelson_validated Exclusive	overlap	0.03	14.40	28.51	11.07	39.07
overlap Exclusive	Nelson_validated Exclusive	0.01	3.02	7.16	6.78	11.31
Nelson_validated Exclusive	overlap Exclusive	0.02	2.74	10.16	5.42	10.58
overlap Exclusive	Overlap	0.00	0.54	4.33	4.48	1.87
Nelson_validated Exclusive	Overlap	0.28	957.94	700.88	769.23	102.16
Overlap	Exclusives	0.08	22.32	74.32	18.49	64.36

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
overlap Exclusive	133	132	UGT2A1
Nelson_validated Exclusive	80	75	C6orf105;CDKN2BAS;ZNF259;POM121L9P;LPAL2
Overlap	6	6