Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA_ML Exclusive	Nelson_validated	9.03e-01	6.77e-01	9.58e-01	2.20e-03
Nelson_validated Exclusive	EA_ML	2.20e-01	3.83e-01	5.26e-02	5.31e-01
EA_ML Exclusive	Nelson_validated Exclusive	8.96e-01	5.32e-01	9.93e-01	1.46e-03
Nelson_validated Exclusive	EA_ML Exclusive	2.42e-01	6.65e-01	1.49e-01	3.53e-01
EA_ML Exclusive	Overlap	3.30e-01	4.99e-01	3.48e-01	8.53e-01
Nelson_validated Exclusive	Overlap	1.30e-03	1.30e-03	1.30e-03	1.40e-03
Overlap	Exclusives	2.68e-08	3.97e-08	3.85e-17	2.41e-08



Evaluating how well EA_ML genes are linked to Nelson_validated genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA_ML Exclusive	Nelson_validated	0.62	0.39	1.26	0.38	3.48
Nelson_validated Exclusive	EA_ML	0.51	1.21	0.85	0.84	0.34
EA_ML Exclusive	Nelson_validated Exclusive	0.62	0.66	1.49	0.55	3.97
Nelson_validated Exclusive	EA_ML Exclusive	0.49	0.59	0.21	0.27	-0.57
EA_ML Exclusive	Overlap	0.52	-1.46	-0.74	-1.30	0.18
Nelson_validated Exclusive	Overlap	0.91	3.17	3.13	3.20	3.03
Overlap	Exclusives	0.63	3.08	5.55	2.94	5.43

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA_ML Exclusive	Nelson_validated	0.01	0.02	0.75	-0.09	0.81
Nelson_validated Exclusive	EA_ML	0.02	36.67	25.00	21.29	19.92
EA_ML Exclusive	Nelson_validated Exclusive	0.01	0.14	0.96	0.17	1.63
Nelson_validated Exclusive	EA_ML Exclusive	0.01	1.41	0.44	-0.05	-0.36
EA_ML Exclusive	Overlap	0.00	-0.86	-0.54	-0.74	-0.11
Nelson_validated Exclusive	Overlap	0.27	868.96	665.68	1265.44	515.61
Overlap	Exclusives	0.06	42.09	64.85	29.13	51.56

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA_ML Exclusive	106	105	ZNF23
Nelson_validated Exclusive	81	76	LPAL2;POM121L9P;ZNF259;CDKN2BAS;C6orf105
Overlap	5	5