Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wavelet Exclusive	Nelson_validated	2.44e-01	3.85e-01	2.79e-13	5.41e-07
Nelson_validated Exclusive	wavelet	2.66e-03	9.02e-02	3.11e-07	8.45e-13
wavelet Exclusive	Nelson_validated Exclusive	4.35e-01	4.32e-01	9.15e-12	9.17e-06
Nelson_validated Exclusive	wavelet Exclusive	1.31e-03	3.43e-01	3.03e-06	5.88e-12
wavelet Exclusive	Overlap	7.21e-01	2.13e-01	1.67e-03	1.44e-02
Nelson_validated Exclusive	Overlap	1.64e-04	1.64e-04	1.64e-04	1.84e-04
Overlap	Exclusives	2.96e-15	1.22e-11	1.97e-34	1.64e-35



Evaluating how well wavelet genes are linked to Nelson_validated genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet Exclusive	Nelson_validated	0.69	1.75	1.69	2.40	5.60
Nelson_validated Exclusive	wavelet	0.72	-1.11	1.82	1.11	8.31
wavelet Exclusive	Nelson_validated Exclusive	0.68	1.98	1.32	2.14	5.37
Nelson_validated Exclusive	wavelet Exclusive	0.71	-1.83	1.33	0.95	7.75
wavelet Exclusive	Overlap	0.85	1.05	1.78	1.79	2.92
Nelson_validated Exclusive	Overlap	0.92	2.70	2.98	3.18	3.96
Overlap	Exclusives	0.80	4.31	8.41	4.46	14.79

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet Exclusive	Nelson_validated	0.01	1.48	1.59	2.18	2.50
Nelson_validated Exclusive	wavelet	0.03	5.20	18.59	11.43	34.85
wavelet Exclusive	Nelson_validated Exclusive	0.01	1.86	1.24	2.52	4.84
Nelson_validated Exclusive	wavelet Exclusive	0.01	-0.64	3.39	2.74	13.02
wavelet Exclusive	Overlap	0.00	-0.27	1.05	1.62	0.95
Nelson_validated Exclusive	Overlap	0.27	317.14	686.40	766.44	711.42
Overlap	Exclusives	0.09	37.63	72.09	41.38	73.83

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wavelet Exclusive	120	120	
Nelson_validated Exclusive	80	75	C6orf105;ZNF259;LPAL2;POM121L9P;CDKN2BAS
Overlap	6	6