Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPIMUTESTR Exclusive	Nelson_validated	3.67e-01	1.87e-01	8.91e-01	3.43e-02
Nelson_validated Exclusive	EPIMUTESTR	2.92e-05	3.56e-01	2.80e-01	7.05e-01
EPIMUTESTR Exclusive	Nelson_validated Exclusive	5.49e-01	1.70e-01	8.99e-01	3.06e-02
Nelson_validated Exclusive	EPIMUTESTR Exclusive	5.12e-05	1.50e-01	5.05e-01	6.17e-01
EPIMUTESTR Exclusive	Overlap	7.84e-01	7.12e-01	8.67e-01	6.59e-01
Nelson_validated Exclusive	Overlap	1.38e-03	1.38e-03	1.38e-03	1.38e-03
Overlap	Exclusives	8.39e-05	2.49e-05	1.87e-24	7.95e-08



Evaluating how well EPIMUTESTR genes are linked to Nelson_validated genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPIMUTESTR Exclusive	Nelson_validated	0.58	-1.28	-2.47	-1.13	2.33
Nelson_validated Exclusive	EPIMUTESTR	0.49	-2.34	-1.31	-1.39	-0.39
EPIMUTESTR Exclusive	Nelson_validated Exclusive	0.58	-1.18	-2.25	-1.24	2.42
Nelson_validated Exclusive	EPIMUTESTR Exclusive	0.49	-2.51	-1.89	-1.77	-0.71
EPIMUTESTR Exclusive	Overlap	0.64	-0.66	-0.32	-0.66	0.97
Nelson_validated Exclusive	Overlap	1.00	2.89	3.21	2.83	3.07
Overlap	Exclusives	0.60	2.56	5.26	2.57	6.17

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPIMUTESTR Exclusive	Nelson_validated	0.01	-1.00	-2.12	-0.91	0.30
Nelson_validated Exclusive	EPIMUTESTR	0.01	2.14	1.73	1.87	1.54
EPIMUTESTR Exclusive	Nelson_validated Exclusive	0.00	-1.02	-2.11	-1.03	0.36
Nelson_validated Exclusive	EPIMUTESTR Exclusive	0.01	-1.60	-1.24	-1.20	-0.78
EPIMUTESTR Exclusive	Overlap	0.00	-0.34	-0.17	-0.27	0.02
Nelson_validated Exclusive	Overlap	0.13	101.76	196.24	69.82	959.78
Overlap	Exclusives	0.03	9.55	17.56	11.02	17.45

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPIMUTESTR Exclusive	238	235	43718;KIAA1199;FNTB.CHURC1.FNTB.CHURC1.FNTB
Nelson_validated Exclusive	83	78	C6orf105;LPAL2;POM121L9P;CDKN2BAS;ZNF259
Overlap	3	3