Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA_ML Exclusive	Literature	7.79e-01	4.13e-01	2.34e-01	2.43e-02
Literature Exclusive	EA_ML	9.77e-02	2.56e-01	1.23e-01	1.04e-01
EA_ML Exclusive	Literature Exclusive	7.49e-01	2.25e-01	6.15e-01	1.13e-02
Literature Exclusive	EA_ML Exclusive	8.04e-02	1.69e-01	4.61e-01	4.63e-02
EA_ML Exclusive	Overlap	3.37e-01	5.07e-01	2.80e-01	9.54e-01
Literature Exclusive	Overlap	1.69e-04	1.69e-04	1.69e-04	1.69e-04
Overlap	Exclusives	1.96e-08	1.14e-08	2.78e-14	5.31e-09



Evaluating how well EA_ML genes are linked to Literature genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA_ML Exclusive	Literature	0.62	-0.00	0.94	-0.26	3.58
Literature Exclusive	EA_ML	0.48	0.28	-0.19	-0.26	-0.78
EA_ML Exclusive	Literature Exclusive	0.63	0.11	1.23	0.10	3.24
Literature Exclusive	EA_ML Exclusive	0.46	-0.19	-0.85	-0.69	-1.65
EA_ML Exclusive	Overlap	0.52	-1.18	-0.72	-1.38	0.19
Literature Exclusive	Overlap	1.00	3.86	2.93	3.52	3.13
Overlap	Exclusives	0.62	3.28	5.81	3.30	6.09

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA_ML Exclusive	Literature	0.00	-0.08	0.70	-0.23	2.30
Literature Exclusive	EA_ML	0.02	33.90	29.29	19.98	23.22
EA_ML Exclusive	Literature Exclusive	0.00	0.07	1.29	0.00	1.58
Literature Exclusive	EA_ML Exclusive	0.01	1.33	0.16	-0.25	-0.60
EA_ML Exclusive	Overlap	0.00	-0.44	-0.45	-0.88	-0.35
Literature Exclusive	Overlap	0.35	56.89	966.29	1517.10	1388.06
Overlap	Exclusives	0.06	46.39	84.40	47.18	58.95

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA_ML Exclusive	107	106	ZNF23
Literature Exclusive	59	54	PSCK9;CDKN2BAS1;LPAL2;ZNF259;RALI
Overlap	4	4